Systemic Amyloidosis

DC 7799-7710Hematologic/Lymphatic38 CFR 4.117, DC 7799-7710

A condition where abnormal proteins called amyloid build up in your organs, causing them to not work properly. It can affect your heart, kidneys, nerves, and liver. The VA rates systemic amyloidosis based on which organs are involved and how much function you have lost.

How the VA rates this condition

The VA rates this condition based on how much it affects your ability to work and carry out daily activities. The examiner will focus on the functional limitations your condition causes, not just the diagnosis itself.

Diagnostic code

DC 7799-7710

Rating range

10% – 100%

Rating levels

Rating criteria are defined in 38 CFR 4.117, DC 7799-7710. This guide presents a plain-language summary and is not a substitute for the full regulatory text. Always consult a VSO or VA-accredited attorney for case-specific advice.

Rating Levels

Your amyloidosis has caused severe organ failure in the heart, kidneys, or other vital organs. You are unable to work and need ongoing intensive treatment.

What the VA looks for

Advanced cardiac amyloidosis with heart failure (NYHA Class III-IV)
End-stage renal disease requiring dialysis
Liver failure from hepatic amyloid infiltration
Unable to maintain gainful employment
Stem cell transplant evaluation or completed

Common Pitfalls

⚠Not obtaining a tissue biopsy with amyloid typing — the VA requires pathological confirmation of amyloid deposits, and typing (AL, AA, ATTR) determines the cause and treatment approach.
⚠Failing to file separate claims for each organ affected — cardiac, renal, neurological, and hepatic involvement can each be rated under their respective body system rating schedules.
⚠Not connecting amyloidosis to service-related exposures — certain environmental exposures, chronic infections during service, and Agent Orange exposure have been linked to amyloid-producing conditions.
⚠Not documenting cardiac biomarkers (BNP, troponin) regularly — these blood tests track heart involvement and are critical for establishing severity.

Related DBQ Forms

DBQ Hematologic and Lymphatic Conditions

View evidence checklist →See secondary conditions →

Condition Rating Guides

Understand what the VA looks for at each rating level — loading conditions…

Systemic Amyloidosis

How the VA rates this condition

Diagnostic code

DC 7799-7710

Rating range

10% – 100%

Rating levels

Rating Levels

Your amyloidosis has caused severe organ failure in the heart, kidneys, or other vital organs. You are unable to work and need ongoing intensive treatment.

What the VA looks for

Advanced cardiac amyloidosis with heart failure (NYHA Class III-IV)
End-stage renal disease requiring dialysis
Liver failure from hepatic amyloid infiltration
Unable to maintain gainful employment
Stem cell transplant evaluation or completed

Common Pitfalls

⚠Not obtaining a tissue biopsy with amyloid typing — the VA requires pathological confirmation of amyloid deposits, and typing (AL, AA, ATTR) determines the cause and treatment approach.

⚠Failing to file separate claims for each organ affected — cardiac, renal, neurological, and hepatic involvement can each be rated under their respective body system rating schedules.

⚠Not connecting amyloidosis to service-related exposures — certain environmental exposures, chronic infections during service, and Agent Orange exposure have been linked to amyloid-producing conditions.

⚠Not documenting cardiac biomarkers (BNP, troponin) regularly — these blood tests track heart involvement and are critical for establishing severity.